Difficult protein production made simple.
A next-generation expression system for next-generation therapeutics.
Our photomolecular platform integrates advanced optogenetic tools with closed-loop precision for dynamic cellular control. By using light, we unlock the production of difficult-to-produce proteins, while improving yield, consistency, and speed to clinic. Designed for scalability, our modular solutions adapt to your business needs, with expert collaboration and technical support at every step.
Whether due to host toxicity, short half life, complex post-translational modifications, or host signaling issues — we can address proteins that are difficult to produce using two control levers:
- Light-inducible transcriptional control separates growth and production and can precisely tune transcriptional pulses to find a rate of production that works for your protein.
- Light-inducible control over secretory capacity enlarges the endoplasmic reticulum and Golgi and increases chaperones, designed for your most difficult to produce products.
We enable lower cost, higher quality antibody therapeutic production by maximizing protein titer, improving protein quality consistency, and reducing doubling time.
Our technology has robust applications across biomanufacturing, including the development of viral vectors, disease models, nutritional proteins, and cultured meat.
A new infrastructure layer for biology.
Closed-loop control
Our smart control system continuously monitors and adjusts illumination in real time.
Optogenetic toolkit
Our genetic constructs can control every major cellular function in any cell type.
Illumination systems
Our easy-to-integrate light embodiments provide precise, efficient control from benchtop to production scale.
Our light control and genetic constructs interact directly with your biology.
We can precisely control any cellular function in any cell type by activating photosensitive receptors. When met with the right wavelength of light, these protein switches come together.
Our technology solves a number of challenges in protein production.
Prolific approach
Standard approach
Separating cell growth from protein production
Prolific approach
Optimizing cellular resources
Prolific approach
Eliminating growth factors
Simple Solutions. Multiple Possibilities.
Do you have a therapeutic protein with yield issues? Contact us for a risk-free manufacturability assessment.
Recent News
Prolific Machines Appoints Former Catalent Chief Scientific Officer to Board of Directors
Prolific Machines Announces the Completion of Optogenetic Bioproduction at 200L, Marking the World’s Largest Demonstration of Optogenetics to Date
Prolific Machines Announces the Appointment of Former Forge Biologics Executive, Christina Perry, as CFO Setting the Stage for Optogenetics Leader’s Biopharmaceutical Commercial Ramp Up
FAQs
Our photomolecular platform brings together genetic tools, hardware, and closed-loop software to precisely control and optimize cellular behavior to more efficiently produce superior bio-product solutions across wide-ranging applications, from food to pharmaceuticals.
Methods currently used to make bio-products are limited to imprecise, inefficient, and expensive control levers, like temperature, chemicals, and proteins to indirectly control cells. Prolific’s platform brings together safe and effective tools to unlock unparalleled, direct control, and precision.
Living organisms have the ability to sense light because of light sensitive proteins (LSP). These naturally occurring proteins are found everywhere, from plants and bacteria to human retinas, and exist to detect and respond to light. They can do this very quickly to cause action in cells within seconds.
Proteins are at the heart of everything a cell does, from perceiving signals from other cells to switching genes on or off. By attaching LSPs to proteins that you want to control within the cell, Prolific makes it possible to precisely control subcellular biology using light. When met with light, which acts as a signal, these LSP can precisely control key functions within cells.
Prolific unlocks dynamic control by pulsating light in specific patterns, intensities, and wavelengths to activate cellular functions when and where it matters most, which is a gamechanger for biomanufacturing.
We’re co-developing the future of biology with innovators and leaders across biopharmaceuticals and advanced nutrition. Examples include proteins found in supplements and infant formula, antibodies to treat diseases, whole cuts of cultured meat, higher fidelity disease models, and other innovations never before possible.
Yes, safety is a key benefit of our platform. Consistency is also a major advantage, which further increases the safety of our technology and process. Light is an abundant, highly controllable, and predictable input that has played a role in cellular control in countless organisms since the dawn of time.
Our process uses light, which acts as a signal to control the light-sensitive proteins (LSP) and direct cellular behavior. We procure these from a wide range of natural sources, including widely consumed plant foods like cabbage, mustard greens, and spirulina.
We use ‘non-ionizing’ light at relatively low intensities in our process, which means it doesn’t carry enough energy to harm living cells. It is safe for use in the production of both food and non-food products.